Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor

The alarmone nucleotide (p)ppGpp is a key regulator of bacterial metabolism, growth, stress tolerance and virulence, making (p)ppGpp-mediated signaling a promising target for development of antibacterials. Although ppGpp itself is an activator of the ribosome-associated ppGpp synthetase RelA, severa...

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Vydáno v:Sci Rep
Hlavní autoři: Beljantseva, Jelena, Kudrin, Pavel, Jimmy, Steffi, Ehn, Marcel, Pohl, Radek, Varik, Vallo, Tozawa, Yuzuru, Shingler, Victoria, Tenson, Tanel, Rejman, Dominik, Hauryliuk, Vasili
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291098/
https://ncbi.nlm.nih.gov/pubmed/28157202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41839
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