Subinhibitory Concentrations of Bacteriostatic Antibiotics Induce relA-Dependent and relA-Independent Tolerance to β-Lactams

The nucleotide (p)ppGpp is a key regulator of bacterial metabolism, growth, stress tolerance, and virulence. During amino acid starvation, the Escherichia coli (p)ppGpp synthetase RelA is activated by deacylated tRNA in the ribosomal A-site. An increase in (p)ppGpp is believed to drive the formation...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Kudrin, Pavel, Varik, Vallo, Oliveira, Sofia Raquel Alves, Beljantseva, Jelena, Del Peso Santos, Teresa, Dzhygyr, Ievgen, Rejman, Dominik, Cava, Felipe, Tenson, Tanel, Hauryliuk, Vasili
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
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Mechanisms of Action: Physiological Effects
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365698/
https://ncbi.nlm.nih.gov/pubmed/28115345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02173-16
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