Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

During the stringent response, Escherichia coli enzyme RelA produces the ppGpp alarmone, which in turn regulates transcription, translation and replication. We show that ppGpp dramatically increases the turnover rate of its own ribosome-dependent synthesis by RelA, resulting in direct positive regul...

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Autors principals: Shyp, Viktoriya, Tankov, Stoyan, Ermakov, Andrey, Kudrin, Pavel, English, Brian P, Ehrenberg, Måns, Tenson, Tanel, Elf, Johan, Hauryliuk, Vasili
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
Matèries:
Scientific Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432798/
https://ncbi.nlm.nih.gov/pubmed/22814757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.106
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