Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

During the stringent response, Escherichia coli enzyme RelA produces the ppGpp alarmone, which in turn regulates transcription, translation and replication. We show that ppGpp dramatically increases the turnover rate of its own ribosome-dependent synthesis by RelA, resulting in direct positive regul...

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Autori principali: Shyp, Viktoriya, Tankov, Stoyan, Ermakov, Andrey, Kudrin, Pavel, English, Brian P, Ehrenberg, Måns, Tenson, Tanel, Elf, Johan, Hauryliuk, Vasili
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
Soggetti:
Scientific Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432798/
https://ncbi.nlm.nih.gov/pubmed/22814757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.106
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