Homogentisate 1,2 Dioxygenase is Expressed in Human Osteoarticular Cells: Implications in Alkaptonuria

Alkaptonuria (AKU) results from defective homogentisate1,2-dioxygenase (HGD), causing degenerative arthropathy. The deposition of ochronotic pigment in joints is so far attributed to homogentisic acid produced by the liver, circulating in the blood and accumulating locally. Human normal and AKU oste...

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Autori principali: Laschi, Marcella, Tinti, Laura, Braconi, Daniela, Millucci, Lia, Ghezzi, Lorenzo, Amato, Loredana, Selvi, Enrico, Spreafico, Adriano, Bernardini, Giulia, Santucci, Annalisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley Subscription Services, Inc., A Wiley Company 2012
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Original Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427883/
https://ncbi.nlm.nih.gov/pubmed/22105303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24018
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