Homogentisate 1,2 Dioxygenase is Expressed in Human Osteoarticular Cells: Implications in Alkaptonuria

Alkaptonuria (AKU) results from defective homogentisate1,2-dioxygenase (HGD), causing degenerative arthropathy. The deposition of ochronotic pigment in joints is so far attributed to homogentisic acid produced by the liver, circulating in the blood and accumulating locally. Human normal and AKU oste...

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Détails bibliographiques
Auteurs principaux: Laschi, Marcella, Tinti, Laura, Braconi, Daniela, Millucci, Lia, Ghezzi, Lorenzo, Amato, Loredana, Selvi, Enrico, Spreafico, Adriano, Bernardini, Giulia, Santucci, Annalisa
Format: Artigo
Langue:Inglês
Publié: Wiley Subscription Services, Inc., A Wiley Company 2012
Sujets:
Original Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427883/
https://ncbi.nlm.nih.gov/pubmed/22105303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24018
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