Homogentisate 1,2 Dioxygenase is Expressed in Human Osteoarticular Cells: Implications in Alkaptonuria

Alkaptonuria (AKU) results from defective homogentisate1,2-dioxygenase (HGD), causing degenerative arthropathy. The deposition of ochronotic pigment in joints is so far attributed to homogentisic acid produced by the liver, circulating in the blood and accumulating locally. Human normal and AKU oste...

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Detalhes bibliográficos
Main Authors: Laschi, Marcella, Tinti, Laura, Braconi, Daniela, Millucci, Lia, Ghezzi, Lorenzo, Amato, Loredana, Selvi, Enrico, Spreafico, Adriano, Bernardini, Giulia, Santucci, Annalisa
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2012
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427883/
https://ncbi.nlm.nih.gov/pubmed/22105303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24018
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