Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID

Adenosine acts as anti-inflammatory mediator on the immune system and has been described in regulatory T cell (Treg)–mediated suppression. In the absence of adenosine deaminase (ADA), adenosine and other purine metabolites accumulate, leading to severe immunodeficiency with recurrent infections (ADA...

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Detaylı Bibliyografya
Asıl Yazarlar: Sauer, Aisha V., Brigida, Immacolata, Carriglio, Nicola, Jofra Hernandez, Raisa, Scaramuzza, Samantha, Clavenna, Daniela, Sanvito, Francesca, Poliani, Pietro L., Gagliani, Nicola, Carlucci, Filippo, Tabucchi, Antonella, Roncarolo, Maria Grazia, Traggiai, Elisabetta, Villa, Anna, Aiuti, Alessandro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2012
Konular:
Immunobiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426348/
https://ncbi.nlm.nih.gov/pubmed/22184407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-366781
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