Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID

Adenosine acts as anti-inflammatory mediator on the immune system and has been described in regulatory T cell (Treg)–mediated suppression. In the absence of adenosine deaminase (ADA), adenosine and other purine metabolites accumulate, leading to severe immunodeficiency with recurrent infections (ADA...

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מידע ביבליוגרפי
Main Authors: Sauer, Aisha V., Brigida, Immacolata, Carriglio, Nicola, Jofra Hernandez, Raisa, Scaramuzza, Samantha, Clavenna, Daniela, Sanvito, Francesca, Poliani, Pietro L., Gagliani, Nicola, Carlucci, Filippo, Tabucchi, Antonella, Roncarolo, Maria Grazia, Traggiai, Elisabetta, Villa, Anna, Aiuti, Alessandro
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society of Hematology 2012
נושאים:
Immunobiology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426348/
https://ncbi.nlm.nih.gov/pubmed/22184407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-366781
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