Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID

Adenosine acts as anti-inflammatory mediator on the immune system and has been described in regulatory T cell (Treg)–mediated suppression. In the absence of adenosine deaminase (ADA), adenosine and other purine metabolites accumulate, leading to severe immunodeficiency with recurrent infections (ADA...

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Detalhes bibliográficos
Main Authors: Sauer, Aisha V., Brigida, Immacolata, Carriglio, Nicola, Jofra Hernandez, Raisa, Scaramuzza, Samantha, Clavenna, Daniela, Sanvito, Francesca, Poliani, Pietro L., Gagliani, Nicola, Carlucci, Filippo, Tabucchi, Antonella, Roncarolo, Maria Grazia, Traggiai, Elisabetta, Villa, Anna, Aiuti, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426348/
https://ncbi.nlm.nih.gov/pubmed/22184407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-366781
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