Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients

Mutations in the adenosine deaminase (ADA) gene are responsible for a form of severe combined immunodeficiency (SCID) caused by the lymphotoxic accumulation of ADA substrates, adenosine and 2′-deoxy-adenosine. The molecular mechanisms underlying T-cell dysfunction in humans remain to be elucidated....

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Detalhes bibliográficos
Main Authors: Cassani, Barbara, Mirolo, Massimiliano, Cattaneo, Federica, Benninghoff, Ulrike, Hershfield, Michael, Carlucci, Filippo, Tabucchi, Antonella, Bordignon, Claudio, Roncarolo, Maria Grazia, Aiuti, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2288726/
https://ncbi.nlm.nih.gov/pubmed/18218852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-092429
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