G(s)α Deficiency in the Paraventricular Nucleus of the Hypothalamus Partially Contributes to Obesity Associated with G(s)α Mutations

The G protein α-subunit G(s)α mediates receptor-stimulated cAMP generation. Heterozygous inactivating G(s)α mutations on the maternal allele result in obesity primarily due to reduced energy expenditure in Albright hereditary osteodystrophy patients and in mice. We previously showed that mice with c...

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Hlavní autoři: Chen, Min, Berger, Alta, Kablan, Ahmed, Zhang, Jiandi, Gavrilova, Oksana, Weinstein, Lee S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2012
Témata:
Energy Balance-Obesity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423628/
https://ncbi.nlm.nih.gov/pubmed/22733970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1113
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