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G(s)α Deficiency in the Paraventricular Nucleus of the Hypothalamus Partially Contributes to Obesity Associated with G(s)α Mutations

The G protein α-subunit G(s)α mediates receptor-stimulated cAMP generation. Heterozygous inactivating G(s)α mutations on the maternal allele result in obesity primarily due to reduced energy expenditure in Albright hereditary osteodystrophy patients and in mice. We previously showed that mice with c...

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Bibliografiske detaljer
Main Authors: Chen, Min, Berger, Alta, Kablan, Ahmed, Zhang, Jiandi, Gavrilova, Oksana, Weinstein, Lee S.
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423628/
https://ncbi.nlm.nih.gov/pubmed/22733970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1113
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