G(s)α Deficiency in the Ventromedial Hypothalamus Enhances Leptin Sensitivity and Improves Glucose Homeostasis in Mice on a High-Fat Diet

In both mice and patients with Albright hereditary osteodystrophy, heterozygous inactivating mutations of G(s)α, a ubiquitously expressed G protein that mediates receptor-stimulated intracellular cAMP production, lead to obesity and insulin resistance but only when the mutation is present on the mat...

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Detaylı Bibliyografya
Yayımlandı:Endocrinology
Asıl Yazarlar: Berger, Alta, Kablan, Ahmed, Yao, Catherine, Ho, Thuy, Podyma, Brandon, Weinstein, Lee S., Chen, Min
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Endocrine Society 2016
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733121/
https://ncbi.nlm.nih.gov/pubmed/26671183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1700
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