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G(s)α Deficiency in the Ventromedial Hypothalamus Enhances Leptin Sensitivity and Improves Glucose Homeostasis in Mice on a High-Fat Diet
In both mice and patients with Albright hereditary osteodystrophy, heterozygous inactivating mutations of G(s)α, a ubiquitously expressed G protein that mediates receptor-stimulated intracellular cAMP production, lead to obesity and insulin resistance but only when the mutation is present on the mat...
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| Publicado no: | Endocrinology |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Endocrine Society
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4733121/ https://ncbi.nlm.nih.gov/pubmed/26671183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1700 |
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