G(s)α deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling

OBJECTIVE: G(s)α couples multiple receptors, including the melanocortin 4 receptor (MC4R), to intracellular cAMP generation. Germline inactivating G(s)α mutations lead to obesity in humans and mice. Mice with brain-specific G(s)α deficiency also develop obesity with reduced energy expenditure and lo...

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Publicado en:Mol Metab
Main Authors: Chen, Min, Wilson, Eric A., Cui, Zhenzhong, Sun, Hui, Shrestha, Yogendra B., Podyma, Brandon, Le, Christina H., Naglieri, Benedetta, Pacak, Karel, Gavrilova, Oksana, Weinstein, Lee S.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2019
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601467/
https://ncbi.nlm.nih.gov/pubmed/31014927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.04.005
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