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G(s)α deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling
OBJECTIVE: G(s)α couples multiple receptors, including the melanocortin 4 receptor (MC4R), to intracellular cAMP generation. Germline inactivating G(s)α mutations lead to obesity in humans and mice. Mice with brain-specific G(s)α deficiency also develop obesity with reduced energy expenditure and lo...
Zapisane w:
| Wydane w: | Mol Metab |
|---|---|
| Główni autorzy: | , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Elsevier
2019
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6601467/ https://ncbi.nlm.nih.gov/pubmed/31014927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.04.005 |
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