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G(q)α/G(11)α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity

The G-protein subunits G(q)α and G(11)α (G(q/11)α) couple receptors to phospholipase C, leading to increased intracellular calcium. In this study we investigated the consequences of G(q)/(11)α deficiency in the dorsomedial hypothalamus (DMH), a critical site for the control of energy homeostasis. Mi...

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Detaylı Bibliyografya
Yayımlandı:Am J Physiol Endocrinol Metab
Asıl Yazarlar: Wilson, Eric A., Sun, Hui, Cui, Zhenzhong, Jahnke, Marshal T., Pandey, Mritunjay, Metzger, Peter, Gavrilova, Oksana, Chen, Min, Weinstein, Lee S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2021
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260363/
https://ncbi.nlm.nih.gov/pubmed/33166186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00059.2020
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