G(s)α deficiency in the dorsomedial hypothalamus underlies obesity associated with G(s)α mutations

G(s)α, encoded by Gnas, mediates hormone and neurotransmitter receptor–stimulated cAMP generation. Heterozygous G(s)α-inactivating mutations lead to obesity in Albright hereditary osteodystrophy (AHO) patients, but only when the mutations occur on the maternal allele. This parent-of-origin effect is...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Chen, Min, Shrestha, Yogendra B., Podyma, Brandon, Cui, Zhenzhong, Naglieri, Benedetta, Sun, Hui, Ho, Thuy, Wilson, Eric A., Li, Yong-Qi, Gavrilova, Oksana, Weinstein, Lee S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5272175/
https://ncbi.nlm.nih.gov/pubmed/27991864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88622
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge