G(s)α deficiency in the dorsomedial hypothalamus underlies obesity associated with G(s)α mutations

G(s)α, encoded by Gnas, mediates hormone and neurotransmitter receptor–stimulated cAMP generation. Heterozygous G(s)α-inactivating mutations lead to obesity in Albright hereditary osteodystrophy (AHO) patients, but only when the mutations occur on the maternal allele. This parent-of-origin effect is...

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Vydáno v:J Clin Invest
Hlavní autoři: Chen, Min, Shrestha, Yogendra B., Podyma, Brandon, Cui, Zhenzhong, Naglieri, Benedetta, Sun, Hui, Ho, Thuy, Wilson, Eric A., Li, Yong-Qi, Gavrilova, Oksana, Weinstein, Lee S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5272175/
https://ncbi.nlm.nih.gov/pubmed/27991864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88622
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