G(s)α Deficiency in Adipose Tissue Leads to a Lean Phenotype with Divergent Effects on Cold Tolerance and Diet-Induced Thermogenesis

G(s)α, the G protein which mediates receptor-stimulated cAMP generation, has been implicated as a regulator of adipogenesis and adipose tissue function. Heterozygous G(s)α mutations lead to obesity in Albright hereditary osteodystrophy (AHO) patients and in mice. In this study we generated mice with...

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Hlavní autoři: Chen, Min, Chen, Hui, Nguyen, Annie, Gupta, Divakar, Wang, Jie, Lai, Edwin W., Pacak, Karel, Gavrilova, Oksana, Quon, Michael J., Weinstein, Lee S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863112/
https://ncbi.nlm.nih.gov/pubmed/20374964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.02.013
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