Phenanthrene Metabolism in Smokers: Use of a Two-Step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation

Polycyclic aromatic hydrocarbons (PAHs) in cigarette smoke are among the most likely causes of lung cancer. PAHs require metabolic activation to initiate the carcinogenic process. Phenanthrene (Phe), a noncarcinogenic PAH, was used as a surrogate of benzo[α]pyrene and related PAHs to study the metab...

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Главные авторы: Wang, Jing, Zhong, Yan, Carmella, Steven G., Hochalter, J. Bradley, Rauch, Diane, Oliver, Andrew, Jensen, Joni, Hatsukami, Dorothy K., Upadhyaya, Pramod, Hecht, Stephen S., Zimmerman, Cheryl L.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2012
Предметы:
Metabolism, Transport, and Pharmacogenomics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422526/
https://ncbi.nlm.nih.gov/pubmed/22674470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.194118
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