Phenanthrene Metabolism in Smokers: Use of a Two-Step Diagnostic Plot Approach to Identify Subjects with Extensive Metabolic Activation

Polycyclic aromatic hydrocarbons (PAHs) in cigarette smoke are among the most likely causes of lung cancer. PAHs require metabolic activation to initiate the carcinogenic process. Phenanthrene (Phe), a noncarcinogenic PAH, was used as a surrogate of benzo[α]pyrene and related PAHs to study the metab...

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Detalhes bibliográficos
Main Authors: Wang, Jing, Zhong, Yan, Carmella, Steven G., Hochalter, J. Bradley, Rauch, Diane, Oliver, Andrew, Jensen, Joni, Hatsukami, Dorothy K., Upadhyaya, Pramod, Hecht, Stephen S., Zimmerman, Cheryl L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Metabolism, Transport, and Pharmacogenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422526/
https://ncbi.nlm.nih.gov/pubmed/22674470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.194118
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