Metabolism of [D(10)]Phenanthrene to Tetraols in Smokers for Potential Lung Cancer Susceptibility Assessment: Comparison of Oral and Inhalation Routes of Administration

Polycyclic aromatic hydrocarbons (PAHs) are believed to be among the causative agents for lung cancer in smokers. PAHs require metabolic activation for carcinogenicity. One pathway produces diol epoxides that react with DNA, causing mutations. Because diol epoxides are converted to tetraols, quantit...

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Bibliographische Detailangaben
Hauptverfasser: Zhong, Yan, Wang, Jing, Carmella, Steven G., Hochalter, J. Bradley, Rauch, Diane, Oliver, Andrew, Jensen, Joni, Hatsukami, Dorothy K., Upadhyaya, Pramod, Zimmerman, Cheryl, Hecht, Stephen S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2011
Schlagworte:
Toxicology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126648/
https://ncbi.nlm.nih.gov/pubmed/21515812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.181719
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