Metabolism of [D(10)]Phenanthrene to Tetraols in Smokers for Potential Lung Cancer Susceptibility Assessment: Comparison of Oral and Inhalation Routes of Administration

Polycyclic aromatic hydrocarbons (PAHs) are believed to be among the causative agents for lung cancer in smokers. PAHs require metabolic activation for carcinogenicity. One pathway produces diol epoxides that react with DNA, causing mutations. Because diol epoxides are converted to tetraols, quantit...

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Main Authors: Zhong, Yan, Wang, Jing, Carmella, Steven G., Hochalter, J. Bradley, Rauch, Diane, Oliver, Andrew, Jensen, Joni, Hatsukami, Dorothy K., Upadhyaya, Pramod, Zimmerman, Cheryl, Hecht, Stephen S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2011
Ábhair:
Toxicology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126648/
https://ncbi.nlm.nih.gov/pubmed/21515812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.181719
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