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AIDing antibody diversity by error-prone mismatch repair

The creation of a highly diverse antibody repertoire requires the synergistic activity of a DNA mutator, known as activation-induced deaminase (AID), coupled with an error-prone repair process that recognizes the DNA mismatch catalyzed by AID. Instead of facilitating the canonical error-free respons...

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Hlavní autoři: Chahwan, Richard, Edelmann, Winfried, Scharff, Matthew D, Roa, Sergio
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422444/
https://ncbi.nlm.nih.gov/pubmed/22703640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.smim.2012.05.005
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