MSH2/MSH6 Complex Promotes Error-Free Repair of AID-Induced dU:G Mispairs as well as Error-Prone Hypermutation of A:T Sites

Mismatch repair of AID-generated dU:G mispairs is critical for class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The generation of a previously unavailable Msh2(−/−)Msh6(−/−) mouse has for the first time allowed us to examine the impact of the complete loss of MutSα on lym...

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Detaylı Bibliyografya
Asıl Yazarlar: Roa, Sergio, Li, Ziqiang, Peled, Jonathan U., Zhao, Chunfang, Edelmann, Winfried, Scharff, Matthew D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887398/
https://ncbi.nlm.nih.gov/pubmed/20567595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011182
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