The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double strand break repair and mismatch repair

Loss of the DNA mismatch repair protein MSH3 leads to the development of a variety of tumors in mice without significantly affecting survival rates, suggesting a modulating role for the MutSβ (MSH2-MSH3) complex in late onset tumorigenesis. To better study the role of MSH3 in tumor progression, we c...

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Autors principals: van Oers, Johanna M. M., Edwards, Yasmin, Chahwan, Richard, Zhang, Weijia, Smith, Cameron, Pechuan, Joaquín, Schaetzlein, Sonja, Jin, Bo, Wang, Yuxun, Bergman, Aviv, Scharff, Matthew D., Edelmann, Winfried
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961563/
https://ncbi.nlm.nih.gov/pubmed/24013230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.365
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