Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells

BACKGROUND: The evolutionarily conserved DNA mismatch repair (MMR) system corrects base-substitution and insertion-deletion mutations generated during erroneous replication. The mutation or inactivation of many MMR factors strongly predisposes to cancer, where the resulting tumors often display resi...

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Detalhes bibliográficos
Main Authors: Tosti, Elena, Katakowski, Joseph A, Schaetzlein, Sonja, Kim, Hyun-Soo, Ryan, Colm J, Shales, Michael, Roguev, Assen, Krogan, Nevan J, Palliser, Deborah, Keogh, Michael-Christopher, Edelmann, Winfried
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189729/
https://ncbi.nlm.nih.gov/pubmed/25302077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-014-0068-4
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