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Quantitative genetic-interaction mapping in mammalian cells
Mapping genetic interactions (GIs) by simultaneously perturbing pairs of genes is a powerful tool for understanding complex biological phenomena. Here we describe an experimental platform for generating quantitative GI maps in mammalian cells using a combinatorial RNA interference strategy. We perfo...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3641890/ https://ncbi.nlm.nih.gov/pubmed/23407553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2398 |
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