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Genetic interaction mapping in mammalian cells using CRISPR interference
We describe a combinatorial CRISPR interference (CRISPRi) screening platform for mapping genetic interactions in mammalian cells. We targeted 107 chromatin-regulation factors in human cells with pools of either single or double single guide RNAs (sgRNAs) to downregulate individual genes or gene pair...
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| Publicado no: | Nat Methods |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5584685/ https://ncbi.nlm.nih.gov/pubmed/28481362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4286 |
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