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The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination
Antibody diversification through somatic hypermutation (SHM) and class switch recombination (CSR) are similarly initiated in B cells with the generation of U:G mismatches by activation-induced cytidine deaminase but differ in their subsequent mutagenic consequences. Although SHM relies on the genera...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3328365/ https://ncbi.nlm.nih.gov/pubmed/22451719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111531 |
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