The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination

Antibody diversification through somatic hypermutation (SHM) and class switch recombination (CSR) are similarly initiated in B cells with the generation of U:G mismatches by activation-induced cytidine deaminase but differ in their subsequent mutagenic consequences. Although SHM relies on the genera...

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Bibliographische Detailangaben
Hauptverfasser: Chahwan, Richard, van Oers, Johanna M.M., Avdievich, Elena, Zhao, Chunfang, Edelmann, Winfried, Scharff, Matthew D., Roa, Sergio
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2012
Schlagworte:
Brief Definitive Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328365/
https://ncbi.nlm.nih.gov/pubmed/22451719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111531
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