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Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks
ATM and ATR are two master checkpoint kinases activated by double-strand DNA breaks (DSBs). ATM is critical for the initial response and the subsequent ATR activation. Here, we show that ATR activation is coupled with loss of ATM activation, an unexpected ATM-to-ATR switch during the biphasic DSB re...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2675165/ https://ncbi.nlm.nih.gov/pubmed/19285939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.01.024 |
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