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Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

ATM and ATR are two master checkpoint kinases activated by double-strand DNA breaks (DSBs). ATM is critical for the initial response and the subsequent ATR activation. Here, we show that ATR activation is coupled with loss of ATM activation, an unexpected ATM-to-ATR switch during the biphasic DSB re...

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Bibliografiske detaljer
Main Authors: Shiotani, Bunsyo, Zou, Lee
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675165/
https://ncbi.nlm.nih.gov/pubmed/19285939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.01.024
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