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Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1
The ATR kinase is a master regulator of the DNA damage response. Yet, how ATR is activated towards different substrates is still poorly understood. Here, we show that ATR phosphorylates Chk1 and RPA32 through distinct mechanisms at replication-associated DNA double-stranded breaks (DSBs). In contras...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3680100/ https://ncbi.nlm.nih.gov/pubmed/23684611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.04.018 |
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