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ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation
The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase is a master checkpoint regulator safeguarding the genome. Upon DNA damage, the ATR-ATRIP complex is recruited to sites of DNA damage by RPA-coated single-stranded DNA and activated by an elusive process. Here, we show that ATR is transf...
Gorde:
| Egile Nagusiak: | , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2011
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3155885/ https://ncbi.nlm.nih.gov/pubmed/21777809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.06.019 |
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