ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation

The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase is a master checkpoint regulator safeguarding the genome. Upon DNA damage, the ATR-ATRIP complex is recruited to sites of DNA damage by RPA-coated single-stranded DNA and activated by an elusive process. Here, we show that ATR is transf...

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Détails bibliographiques
Auteurs principaux: Liu, Shizhou, Shiotani, Bunsyo, Lahiri, Mayurika, Maréchal, Alexandre, Tse, Alice, Leung, Charles Chung Yun, Mark Glover, J. N., Yang, Xiaohong H., Zou, Lee
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155885/
https://ncbi.nlm.nih.gov/pubmed/21777809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.06.019
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