Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

PTEN is a tumor suppressor gene mutated in various advanced human neoplasias, including glioblastomas and prostate, breast, endometrial, and kidney cancers. This tumor suppressor is a lipid phosphatase that negatively regulates cell survival and proliferation mediated by phosphatidylinositol 3-kinas...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Backman, Stéphanie A., Ghazarian, Danny, So, Kelvin, Sanchez, Otto, Wagner, Kay-Uwe, Hennighausen, Lothar, Suzuki, Akira, Tsao, Ming-Sound, Chapman, William B., Stambolic, Vuk, Mak, Tak W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC341836/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14747659/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0308217100
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