Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

PTEN is a tumor suppressor gene mutated in various advanced human neoplasias, including glioblastomas and prostate, breast, endometrial, and kidney cancers. This tumor suppressor is a lipid phosphatase that negatively regulates cell survival and proliferation mediated by phosphatidylinositol 3-kinas...

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Detalhes bibliográficos
Main Authors: Backman, Stéphanie A., Ghazarian, Danny, So, Kelvin, Sanchez, Otto, Wagner, Kay-Uwe, Hennighausen, Lothar, Suzuki, Akira, Tsao, Ming-Sound, Chapman, William B., Stambolic, Vuk, Mak, Tak W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC341836/
https://ncbi.nlm.nih.gov/pubmed/14747659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308217100
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