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grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten(+/-) mice
PTEN is a tumor suppressor gene implicated in both sporadic cancers and inherited tumor-prone syndromes. Here we show that pten(+/-) mice display a partially penetrant embryonic lethality. This lethality is associated with defects in both neural and placental development. Notably, this lethality is...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC524460/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15492213/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0406613101 |
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