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grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten(+/-) mice
PTEN is a tumor suppressor gene implicated in both sporadic cancers and inherited tumor-prone syndromes. Here we show that pten(+/-) mice display a partially penetrant embryonic lethality. This lethality is associated with defects in both neural and placental development. Notably, this lethality is...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC524460/ https://ncbi.nlm.nih.gov/pubmed/15492213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406613101 |
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