Heterozygosity for Pten Promotes Tumorigenesis in a Mouse Model of Medulloblastoma

BACKGROUND: Recent publications have described an important role for cross talk between PI-3 kinase and sonic hedgehog signaling pathways in the pathogenesis of medulloblastoma. METHODOLOGY/PRINCIPAL FINDINGS: We crossed mice with constitutive activation of Smoothened, SmoA1, with Pten deficient mic...

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Detalhes bibliográficos
Main Authors: Castellino, Robert C., Barwick, Benjamin G., Schniederjan, Matthew, Buss, Meghan C., Becher, Oren, Hambardzumyan, Dolores, MacDonald, Tobey J., Brat, Daniel J., Durden, Donald L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877103/
https://ncbi.nlm.nih.gov/pubmed/20520772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010849
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