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Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
PTEN is a tumor suppressor gene mutated in various advanced human neoplasias, including glioblastomas and prostate, breast, endometrial, and kidney cancers. This tumor suppressor is a lipid phosphatase that negatively regulates cell survival and proliferation mediated by phosphatidylinositol 3-kinas...
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC341836/ https://ncbi.nlm.nih.gov/pubmed/14747659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308217100 |
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