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Unusual Features of Self-Peptide/MHC Binding by Autoimmune T Cell Receptors

Structural studies on T cell receptors (TCRs) specific for foreign antigens demonstrated a remarkably similar topology characterized by a central, diagonal TCR binding mode that maximizes interactions with the MHC bound peptide. However, three recent structures involving autoimmune TCRs demonstrated...

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Bibliografiske detaljer
Main Authors: Nicholson, Melissa J., Hahn, Michael, Wucherpfennig, Kai W.
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417822/
https://ncbi.nlm.nih.gov/pubmed/16226501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2005.09.009
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