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Structural Alterations in peptide–MHC Recognition by Self-reactive T cell Receptors

The crystal structures of five autoimmune T cell receptor (TCR)–peptide–MHC complexes reveal substantial structural alterations compared to anti-microbial TCRs. The two human TCRs bind their self-peptide–MHC ligands with an altered topology, while the three mouse receptors recognize a self-peptide t...

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Autors principals: Wucherpfennig, Kai W., Call, Melissa J., Deng, Lu, Mariuzza, Roy
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787854/
https://ncbi.nlm.nih.gov/pubmed/19699075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2009.07.008
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