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A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC
Self-reactive T cells that escape elimination in the thymus can cause autoimmune pathology, and it is therefore important to understand the structural mechanisms of self-antigen recognition. We report the crystal structure of a T cell receptor (TCR) from a patient with relapsing-remitting multiple s...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3023130/ https://ncbi.nlm.nih.gov/pubmed/21199956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100725 |
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