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Crystal Structure of the HLA-DM - HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection

HLA-DR molecules bind microbial peptides in an endosomal compartment and present them on the cell surface for CD4 T cell surveillance. HLA-DM plays a critical role in the endosomal peptide selection process. The structure of the HLA-DM – HLA-DR complex shows major rearrangements of the HLA-DR peptid...

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Dettagli Bibliografici
Autori principali: Pos, Wouter, Sethi, Dhruv K., Call, Melissa J., Schulze, Monika-Sarah E. D., Anders, Anne-Kathrin, Pyrdol, Jason, Wucherpfennig, Kai W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530167/
https://ncbi.nlm.nih.gov/pubmed/23260142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.11.025
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