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HLA-DM Captures Partially Empty HLA-DR Molecules for Catalyzed Peptide Removal
The mechanisms of HLA-DM catalyzed peptide exchange remain uncertain. We found that all stages of the interaction of DM with HLA-DR were dependent on the occupancy state of the peptide binding groove. High-affinity peptides were protected from removal by DM through two mechanisms: peptide binding in...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3018327/ https://ncbi.nlm.nih.gov/pubmed/21131964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1967 |
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