HLA-DM Captures Partially Empty HLA-DR Molecules for Catalyzed Peptide Removal

The mechanisms of HLA-DM catalyzed peptide exchange remain uncertain. We found that all stages of the interaction of DM with HLA-DR were dependent on the occupancy state of the peptide binding groove. High-affinity peptides were protected from removal by DM through two mechanisms: peptide binding in...

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Hlavní autoři: Anders, Anne-Kathrin, Call, Melissa J., Schulze, Monika-Sarah E. D., Fowler, Kevin D., Schubert, David A., Seth, Nilufer P., Sundberg, Eric J., Wucherpfennig, Kai W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018327/
https://ncbi.nlm.nih.gov/pubmed/21131964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1967
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