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Disruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class II

Peptide presentation by MHC class II is of critical importance to the function of CD4+ T cells. HLA-DM resides in the endosomal pathway and edits the peptide repertoire of newly synthesized MHC class II molecules before they are exported to the cell surface. HLA-DM ensures MHC class II molecules bin...

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Détails bibliographiques
Auteurs principaux: Schulze, Monika-Sarah E. D., Anders, Anne-Kathrin, Sethi, Dhruv K., Call, Melissa J.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743349/
https://ncbi.nlm.nih.gov/pubmed/23976922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069228
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