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Crystal Structure of the HLA-DM - HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection
HLA-DR molecules bind microbial peptides in an endosomal compartment and present them on the cell surface for CD4 T cell surveillance. HLA-DM plays a critical role in the endosomal peptide selection process. The structure of the HLA-DM – HLA-DR complex shows major rearrangements of the HLA-DR peptid...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3530167/ https://ncbi.nlm.nih.gov/pubmed/23260142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.11.025 |
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