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Recognition of self-peptide–MHC complexes by autoimmune T-cell receptors

T cell receptors (TCR) recognize antigenic peptides displayed by MHC molecules. Whereas T-cell recognition of foreign peptides is essential for immune defense against microbial pathogens, recognition of self-peptides can cause autoimmune disease. Structural studies of anti-foreign TCR showed remarka...

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Autors principals: Deng, Lu, Mariuzza, Roy A.
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739108/
https://ncbi.nlm.nih.gov/pubmed/17950605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2007.08.007
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