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Unconventional topology of self peptide–major histocompatibility complex binding by a human autoimmune T cell receptor
Autoimmune diseases are caused by self-reactive lymphocytes that have escaped deletion. Here we have determined the structure of the trimolecular complex for a T cell receptor (TCR) from a patient with multiple sclerosis that causes autoimmunity in transgenic mice. The structure showed a TCR topolog...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3415330/ https://ncbi.nlm.nih.gov/pubmed/15821740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni1187 |
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