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Unconventional topology of self peptide–major histocompatibility complex binding by a human autoimmune T cell receptor

Autoimmune diseases are caused by self-reactive lymphocytes that have escaped deletion. Here we have determined the structure of the trimolecular complex for a T cell receptor (TCR) from a patient with multiple sclerosis that causes autoimmunity in transgenic mice. The structure showed a TCR topolog...

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Main Authors: Hahn, Michael, Nicholson, Melissa J, Pyrdol, Jason, Wucherpfennig, Kai W
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415330/
https://ncbi.nlm.nih.gov/pubmed/15821740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni1187
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