Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment

Overcoming resistance to chemotherapy is the main therapeutic challenge in the treatment of acute lymphocytic leukemia (ALL). Interactions between leukemia cells and the microenvironment promote leukemia cell survival and confer resistance to chemotherapy. Hypoxia is an integral component of bone ma...

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Main Authors: Frolova, Olga, Samudio, Ismael, Benito, Juliana Maria, Jacamo, Rodrigo, Kornblau, Steven M., Markovic, Ana, Schober, Wendy, Lu, Hongbo, Qiu, Yi Hua, Buglio, Daniela, McQueen, Teresa, Pierce, Sherry, Shpall, Elizabeth, Konoplev, Sergej, Thomas, Deborah, Kantarjian, Hagop, Lock, Richard, Andreeff, Michael, Konopleva, Marina
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414410/
https://ncbi.nlm.nih.gov/pubmed/22785211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.20838
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