Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment

Overcoming resistance to chemotherapy is the main therapeutic challenge in the treatment of acute lymphocytic leukemia (ALL). Interactions between leukemia cells and the microenvironment promote leukemia cell survival and confer resistance to chemotherapy. Hypoxia is an integral component of bone ma...

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Hlavní autoři: Frolova, Olga, Samudio, Ismael, Benito, Juliana Maria, Jacamo, Rodrigo, Kornblau, Steven M., Markovic, Ana, Schober, Wendy, Lu, Hongbo, Qiu, Yi Hua, Buglio, Daniela, McQueen, Teresa, Pierce, Sherry, Shpall, Elizabeth, Konoplev, Sergej, Thomas, Deborah, Kantarjian, Hagop, Lock, Richard, Andreeff, Michael, Konopleva, Marina
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2012
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414410/
https://ncbi.nlm.nih.gov/pubmed/22785211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.20838
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