Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment

We investigated the antileukemia effects and molecular mechanisms of apoptosis induction by simultaneous blockade of PI3K and mutant FLT3 in AML cells grown under hypoxia in co-cultures with bone marrow stromal cells. Combined treatment with selective class I PI3K inhibitor GDC-0941 and sorafenib re...

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Bibliographic Details
Main Authors: Jin, Linhua, Tabe, Yoko, Lu, Hongbo, Borthakur, Gautam, Miida, Takashi, Kantarjian, Hagop, Andreeff, Michael, Konopleva, Marina
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572533/
https://ncbi.nlm.nih.gov/pubmed/23036488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2012.09.020
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