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TREATMENT WITH FLT3 INHIBITOR IN PATIENTS WITH FLT3-MUTATED AML IS ASSOCIATED WITH DEVELOPMENT OF SECONDARY FLT3-TKD MUTATIONS

BACKGROUND: FLT3-internal tandem duplication (ITD) mutations are found in approximately 30% of AML patients. FLT3 inhibitors have shown clinical activity in AML with FLT3-ITD but responses are usually short lived. METHODS: We reviewed 69 FLT3 mutated AML patients, treated with different FLT3 inhibit...

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Main Authors: Alvarado, Yesid, Kantarjian, Hagop, Luthra, Rajyalakshmi, Ravandi, Farhad, Borthakur, Gautam, Garcia-Manero, Guillermo, Konopleva, Marina, Estrov, Zeev, Andreeff, Michael, Cortes, Jorge
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4124083/
https://ncbi.nlm.nih.gov/pubmed/24737502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28705
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